Tumor necrosis factor alpha antibody prevents brain damage of rats with acute necrotizing pancreatitis.
نویسندگان
چکیده
AIM To study the protective effects of tumor necrosis factor alpha (TNFalpha) antibody on pancreatic encephalopathy in rats. METHODS One hundred and twenty SD rats were randomly divided into normal control group, acute necrotizing pancreatitis group and TNFalpha antibody treated group. Acute hemorrhage necrotizing pancreatitis model in rats was induced by retrograde injection of 50 g/L sodium taurocholate into the pancreatobiliary duct. Serum TNFalpha was detected and animals were killed 12 h after drug administration. Changes in content of brain water, MDA and SOD as well as leucocyte adhesion of brain microvessels were measured. RESULTS In TNFalpha antibody treated group, serum TNFalpha level was decreased. Content of brain water, MDA and SOD as well as leucocyte adhesion were decreased significantly in comparison with those of acute necrotizing pancreatitis group (P<0.05). CONCLUSION TNFalpha antibody can alleviate the brain damage of rats with acute hemorrhage necrotizing pancreatitis.
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ورودعنوان ژورنال:
- World journal of gastroenterology
دوره 10 19 شماره
صفحات -
تاریخ انتشار 2004